Laboratorio sperimentale ricerche Biomarcatori Danno d'Organo

ATTIVITÀ DI RICERCA

Valutazione di biomarcatori cellulari e molecolari di malattie complesse quali dismetabolismi, patologia cardiometabolica, patologie da glicazioni.

MALATTIE E BIOMARCATORI OGGETTO DI RICERCA

• Patologia Cardio-Renale;
• CKD/DKD;
• Pathways ST2/IL-33;
• GLP-1;
• Fibrosi Cardiaca;
• NLRP3 pathway;
• RAGE e sottoclassi c, e, s in patologia umana.

RISULTATI DI PARTICOLARE IMPORTANZA RAGGIUNTI

Identificazione di nuovi biomarcatori cellulari e molecolari che intervengono nell’inflammosoma , nel lipidoma e che regolano la suscettibilità a sviluppare obesità, ed in particolare patologie cardiometaboliche.

Glicazioni e sRAGE

• Elena Dozio, Luca Massaccesi, Massimiliano Marco Corsi Romanelli
  Glycation and Glycosylation in Cardiovascular Remodeling: Focus on Advanced Glycation End Products and O-Linked Glycosylations as Glucose-Related Pathogenetic Factors and Disease Markers J Clin Med. 2021 Oct; 10(20): 4792. Published online 2021 Oct 19. doi: 10.3390/jcm10204792 PMCID: PMC8539574
  IF 3.3 Q1
• Elena Dozio, Simone Vettoretti, Giuseppe Lungarella, Piergiorgio Messa, Massimiliano M. Corsi Romanelli
  Sarcopenia in Chronic Kidney Disease: Focus on Advanced Glycation End Products as Mediators and Markers of Oxidative Stress Biomedicines. 2021 Apr; 9(4): 405. Published online 2021 Apr 9. doi: 10.3390/biomedicines9040405 PMCID: PMC8068965
  IF 4.7 Q1 2

Cardio-Nefro

• Elena Vianello, Marta Kalousová, Elena Dozio, Lorenza Tacchini, Tomáš Zima, Massimiliano Marco Corsi Romanelli
  Osteopontin: The Molecular Bridge between Fat and Cardiac–Renal Disorders Int J Mol Sci. 2020 Aug; 21(15): 5568. Published online 2020 Aug 4. doi: 10.3390/ijms21155568 PMCID: PMC7432729
  IF 6.208 Q1
• Elena Dozio, Simone Vettoretti, Lara Caldiroli, Silvia Nerini-Molteni, Lorenza Tacchini, Federico Ambrogi, Piergiorgio Messa, Massimiliano M. Corsi Romanelli
  Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD Biomedicines. 2020 Dec; 8(12): 638. Published online 2020 Dec 21. doi: 10.3390/biomedicines8120638 PMCID: PMC7767383 
  IF 4.7 Q1

ST2/IL-33 and cardiac remodeling

• Elena Vianello, Elena Dozio, Francesco Bandera, Gerd Schmitz, Manuela Nebuloni, Erika Longhi, Lorenza Tacchini, Marco Guazzi, Massimiliano Marco Corsi Romanelli
  Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression Sci Rep. 2019; 9: 10331. Published online 2019 Jul 17. doi: 10.1038/s41598-019- 46676-wCorrection in: Sci Rep. 2020; 10: 1182. PMCID: PMC6637132
  IF 4.379 Q1
• Elena Vianello, Elena Dozio, Francesco Bandera, Marco Froldi, Emanuele Micaglio, John Lamont, Lorenza Tacchini, Gerd Schmitz, Massimiliano Marco Corsi Romanelli
  Correlative Study on Impaired Prostaglandin E2 Regulation in Epicardial Adipose Tissue and Its Role in Maladaptive Cardiac Remodeling via EPAC2 and ST2 Signaling in Overweight Cardiovascular Disease Subjects Int J Mol Sci. 2020 Jan; 3 21(2): 520. Published online 2020 Jan 14. doi: 10.3390/ijms21020520 PMCID: PMC7014202
  IF 6.208 Q1
• Clementina Sitzia, Elena Vianello, Elena Dozio, Marta Kalousová, Tomáš Zima, Stefano Brizzola, Paola Roccabianca, Gabriella Tedeschi, John Lamont, Lorenza Tacchini, Massimiliano Marco Corsi-Romanelli
  Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats. Int J Mol Sci. 2023 Feb; 24(3): 1991. Published online 2023 Jan 19. doi: 10.3390/ijms24031991 PMCID: PMC9916239
  F 6.208 Q1

D. GLP-1 e rischio cardiometabolico

• Elena Dozio , Elena Vianello, Alexis E. Malavazos, Lorenza Tacchini , Gerd Schmitz , Gianluca Iacobellis , Massimiliano M. Corsi Romanelli
  Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: A target to modulate cardiovascular risk? International Journal of Cardiology Volume 292, 1 October 2019, Pages 218-224.
  IF 4.09 Q2
• Alexis Elias Malavazos, Gianluca Iacobellis, Elena Dozio, Sara Basilico, Angelica Di Vincenzo, Carola Dubini, Lorenzo Menicanti, Elena Vianello, Chiara Meregalli, Chiara Ruocco, Francesco Secchi, Pietro Spagnolo, Serenella Castelvecchio, Lelio Morricone, Silvio Buscemi, Antonio Giordano, Jeffrey J Goldberger, Michele Carruba, Saverio Cinti, Massimiliano Marco Corsi Romanelli, Enzo Nisoli
  Human Epicardial Adipose Tissue Expresses Glucose-dependent Insulinotropic Polypeptide, Glucagon and Glucagon-Like Peptide 1 Receptors as Potential Targets of Pleiotropic Therapies
  European Journal of Preventive Cardiology, zwad050, https://doi.org/10.1093/eurjpc/zwad050 Published:17 February 2023
  IF 8.526 Q1 4

PRINCIPALI COLLABORAZIONI

• Institute of Medical Biochemistry and Laboratory Diagnostic, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12108 Prague, Czech Republic ;
• Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami, FL, USA;
• Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy;
• Department of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany;
• IRCCS Policlinico San Donato, San Donato Milanese, P.za Edmondo Malan 1, Italia (RETE CARDIOVASCOLARE).

COMPONENTI DEL LABORATORIO SPERIMENTALE

• Prof.ssa Elena DOZIO, PhD Associato di Patologia Clinica;
• Dr. Luca MASSACCESI, FRCB, Aggregato di Scienze e Tecniche di Medicina di Laboratorio;
• Prof.ssa  Lorenza TACCHINI, PhD Associato di Patologia Generale;
• Dr.ssa Elena VIANELLO, PhD, RTD-B di Patologia Clinica;
• Prof. Massimiliano M. CORSI ROMANELLI, MD PhD Ordinario di Patologia Clinica.