Dott.ssa Cecilia Invitti

Professore a contratto presso la scuola di specializzazione in Ematologia dell’Università di Milano nel periodo 1987-1999. Responsabile scientifico di progetti finalizzati ministeriali e sperimentazioni in ambito diabetologico/metabolico secondo le GCP dal 1999 a oggi. Paper reviewer per riviste scientifiche internazionali.

Nei primi 20 anni della sua attività clinica si è occupata in particolare di tumori ipofisari e surrenalici e di sindrome di Cushing. Negli anni successivi, pur continuando a svolgere attività clinica su tutte le patologie endocrine, si è prevalentemente occupata di diabete, obesità dell’adulto ed infantile, sindrome metabolica e ipertensione endocrina e prevenzione. cardiovascolare con lo stile di vita.

Nei primi 20 anni ha svolto attività di ricerca su patologie ipofisarie e surrenaliche, in particolare la sindrome di Cushing e sull’anoressia nervosa. Successivamente, i suoi campi di ricerca sono stati la fisiopatologia del diabete di tipo 2, le complicanze metaboliche e cardiovascolari nell'obesità adulta ed infantile, l’effetto di diversi interventi terapeutici sullo stile di vita o farmacologici nel prevenire le complicanze cardio-metaboliche. Da anni studia con ricerche di base il ruolo che un tessuto adiposo disfunzionale svolge nello sviluppo di complicanze cardio-metaboliche e gli effetti dei metaboliti della dieta sulla biologia adipocitaria.

Autore di 200 lavori su peer reviewed Journals e più di 300 presentazioni a congressi internazionali e nazionali.

Selezione delle pubblicazioni:

• Invitti C., Pecori Giraldi F., De Martin M., Cavagnini F. and the Multicentre Study Group of the Italian Society of Endocrinology: Diagnosis and  management of Cushing’s syndrome: results of an Italian Multicentre Sudy. Journal of Clinical Endocrinology and Metabolism 84:440-48:1999.
• Invitti C., Pecori Giraldi F., Cavagnini F., and the Study Group on the   Hypothalamo Pituitary Adrenal Axis of the Italian Society of Endocrinology: Diagnostic yield of inferior petrosal sinus sampling in patients with ACTH-dependent Cushing’s syndrome and contradictory responses to dynamic testing. Clinical Endocrinology, 51:255-61,1999.
• Invitti C., Guzzaloni G., Gilardini L., Morabito F., Viberti G.: Prevalence and concomitans of glucose intolerance  in European obese children and adolescents. Diabetes Care 2003, 26; 118-24.
• Invitti C., Gilardini L., Viberti G.C. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;351:1146-48.
• Gilardini L, Girola A, Morabito F, Invitti C Fasting glucose is not useful in identifying obese caucasian children  with impaired glucose tolerance, J Pediatrics 2006, 149;242.
• Gilardini L, McTernan PG, Girola A, da Silva NF, Alberti L, Kumar S, Invitti C. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis, 2006, 189: 401-07.
• Invitti C, Giardini L, Pontiggia B, Morabito F, Mazzilli G, Viberti G Period prevalence of abnormal glucose tolerance and its concomitans in Italian obese children. NMCD 2006, 16:256-62.
• Invitti C., Maffeis C., Gilardini L., Pontiggia B., Mazzilli G., Morabito F., Viberti G.C. Metabolic sindrome in obese Caucasian children: prevalence using WHO-derived criteria and association with non traditional cardiovascular risk factors. Int J Obesity 2006, 30:627-633.
• Invitti C.,Pasqualinotto L., Croci M., Compare M., Valtorta L., Caffetto K., Macchiella S. Managing obese children and adolescents attending an obesity centre in northerm Italy, Obesity in practice 2006, 1: 8-12
• Lurbe E., Invitti C., Torro I., Maronati A., Aguilar F., Sartorio A., Redon J., Parati G.  The impact of the degree of obesity on the discrepancies between office and ambulatory blood pressure values in youth. J Hypertension 2006, 24:1557-64.
• Alberti L, Gilardini L, Girola A, Moro M, Cavagnini F, Invitti C Adiponectin receptors gene expression in lymphocytes of obese and anorectic patients. Diabetes Obes Metab. 2007; 9:344-49.
• Alberti L, Girola A, Gilardini L, Conti A, Cattaldo S, Micheletto G, Invitti C. Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese  subjects. Int J Obes (Lond). 2007, 31: 1826-31.
• L. Gilardini, G. Parati, A. Sartorio, G. Mazzilli, B. Pontiggia, C. Invitti. Sympathoadrenergic and metabolic factors are involved in ambulatory blood pressure rise in childhood obesity. J Human Hypertension 2008, 22:75-82.
• L. Alberti, L. Gilardini, A Zulian, G Micheletto, G Peri, A Doni, A Mantovani, C Invitti. Expression of long pentraxin PTX3 in human adipose tissue and its relation with cardiovascular risk factors. Atherosclerosis, 2009; 202:4555-460.
• Mantovani G, Bondioni S, Alberti L, Gilardini L, Invitti C, Corbetta S, Zappa MA, Ferrero S, Lania AG, Bosari S, Beck-Peccoz P, Spada A PKA regulatory subunits in human adipose tissue: decreased R2 B expression and activity in adipocytes from obese subjects. Diabetes 2009 ;58:620-26.
• Lurbe E, Cifkova R, Cruickshank JK, Dillon MJ, Ferreira I, Invitti C, Kuznetsova T, Laurent S, Mancia G, Morales-Olivas F, Rascher W, Redon J, Schaefer F, Seeman T, Stergiou G, Wühl E, Zanchetti A; European Society of Hypertension. Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension. J Hypertens. 2009, 27:1719-42.
• Gilardini L, Zulian A, Girola A, Redaelli G, Conti A, Invitti C Predictors of the early impairment of renal disease in human obesity. Int J Obes (Lond). 2010 Feb;34:287-94.
• A. Zulian, R. Cancello, A. Girola, L.Gilardini, L.Alberti, M. Croci, G. Micheletto, P. Danelli, C. Invitti. In vivo and in vitro effects of metformin on adiponectin in human adipose tissue. Obesity facts 2011, 4 :27-33.
• L. Gilardini, L. Pasqualinotto, S. Di Matteo, K. Caffetto, M. Croci, A. Girola,  C. Invitti. Factors associated with early atherosclerosis and arterial calcifications in young subjects with a begnin phenotype of obesity. Obesity 2011; 19:1684-89.
• Zulian A, Cancello R, Micheletto G, Gentilini D, Gilardini L, Danelli P, Invitti C Visceral adipocytes: old actors in obesity and new protagonists in Crohn's disease? Gut  2012; 61:86-94.
• Gilardini L.,Vallone L., Cottafava R., Redaelli G., Croci M., Conti A., Pasqualinotto L., Invitti C. Insulin Sensitivity Deteriorates after Short-Term Lifestyle Intervention in the Insulin Sensitive Phenotype of Obesity. Obesity Facts 2012;5:68-76.
• Mencarelli M., Zulian A., Cancello R., Alberti L., Gilardini L., Di Blasio AM., Invitti C. A novel missense mutation in the signal peptide of the human POMC gene is associated with obesity and early-onset diabetes. Eur J Hum Genet. 2012, 20:1290-4.
• Cancello R, Zulian A, Maestrini S, Mencarelli M,Della Barba A, Invitti C, Liuzzi A, Di Blasio A M. The Nicotinic Acetylcholine Receptor 7 in subcutaneous mature adipocytes: down-regulation in human obesity and modulation by diet-induced weight loss. Int J Obesity 2012;36:1552-57.
• R Cancello, A Zulian, D Gentilini, M Mencarelli, A Della Barba, M Maffei, P Vitti, C Invitti, A Liuzzi, and AM Di Blasio. Permanence of molecular features of obesity in subcutaneous adipose tissue of Ex-obese subjects Int J Obesity 2013, 37:867-73.
• Gilardini L, Lombardi C, Redaelli G, Vallone L, Faini A, Mattaliano P, Parati G, Invitti C Glucose tolerance and weight loss in obese women with obstructive sleep apnea. PLoS One. 2013;8:e61382.
• Cancello R, Zulian A, Gentilini D, Maestrini S, Della Barba A, Corà D, Caselle M, Invitti C, Liuzzi A Di Blasio AM  Molecular and morphologic characterization of superficial- and deep-subcutaneous adipose tissue compartments in morbidly obese patients Obesity 2013;21:2562-70.
• Gilardini L, Croci M, Pasqualinotto l, Caffetto K, Invitti C .Dietary habits and cardiometabolic health in obese children, Obesity facts 2015;8:101-09.
• Varma MC, Kusminski CM, Azharian S, Gilardini L, Kumar S, Invitti C, McTernan PG Metabolic endotoxaemia in childhood obesity. BMC Obes. 2016;3:3. eCollection 2015.
• Proserpio C, Laureati M, Invitti C, Pasqualinotto L, Bergamaschi V, Pagliarini E. Cross-modal interactions for custard desserts differ in obese and normal weight Italian women. Appetite. 2016;100:203-09.
• Di Bonito P, Pacifico L, Chiesa C, Valerio G, Miraglia Del Giudice E, Maffeis C, Morandi A, Invitti C, Licenziati MR, Loche S, Tornese G, Franco F, Manco M, Baroni MG; “CARdiometabolic risk factors in overweight and obese children in ITALY” (CARITALY) Study Group. White blood cell count identify an abnormal cardiometabolic phenotype and preclinical signs of organ damage in obese children and adolescents NMCD 2016, 26:502-09.
• Gilardini L, Redaelli G, Croci M, Conti A, Pasqualinotto L, Invitti C. Effect of a Modest Weight Loss in Normalizing Blood Pressure in Obese Subjects on Antihypertensive Drugs. Obesity Facts. 2016;9:251-58.
• Zulian A, Cancello R,  Ruocco C, Gentilin D, Di Blasio AM, Danelli P, Micheletto G, Cesana E,  Invitti C . Differences in visceral fat and fat bacterial colonization between ulcerative colitis and Crohn's disease. An in vivo and in vitro study PLoS One. 2013 8: e78495.
• A Zulian, R Cancello, E Cesana, E Rizzi, C Consolandi, M Severgnini, V Panizzo, AM Di Blasio, G Micheletto and C Invitti.Adipose tissue microbiota in humans: an open issue . Int J Obes (Lond). 2016;40:1643-48.
• Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, Invitti C, Litwin M, Mancia G, Pall D, Rascher W, Redon J, Schaefer F, Seeman T, Sinha M, Stabouli S, Webb NJ, Wühl E, Zanchetti A. 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens. 2016 34:1887-920.
• Di Bonito P, Pacifico L, Chiesa C, Valerio G, Miraglia Del Giudice E, Maffeis C, Morandi A, Invitti C, Licenziati MR, Loche S, Tornese G, Franco F, Manco M, Baroni MG; “CARdiometabolic risk factors in overweight and obese children in ITALY” (CARITALY) Study Group.Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity. J Endocrinol Invest. 2017; 40:409-16.
• Proserpio, C., Laureati, M., Invitti, C., Cattaneo, C., Pagliarini, E., BMI and gender related differences in cross-modal interaction and liking of sensory stimuli, Food Quality and Preference 56 2017; 56: 49–54;
• Gilardini L, Lombardi C, Redaelli G, Mattaliano P, Fanari P, Cornacchia M, Scacchi M, Mai S, Ferronato P, Parati G, Invitti C Effect of continuous positive airway pressure in hypertensive patients with obstructive sleep apnea and high urinary metanephrines. J Hypertens. 2018 Jan;36(1):199-204;
• Cancello R, Turroni S, Rampelli S, Cattaldo S, Candela M, Cattani L, Mai S, Vietti R, Scacchi M, Brigidi P, Invitti C Effect of Short-Term Dietary Intervention and Probiotic Mix Supplementation on the Gut Microbiota of Elderly Obese Women. Nutrients. 2019 Dec 10;11(12):3011;
• Cancello R, Micheletto G, Meta D, Lavagno R, Bevilacqua E, Panizzo V, Invitti C. Expanding the role of bitter taste receptor in extra oral tissues: TAS2R38 is expressed in human adipocytes. Adipocyte. 2020 Dec;9(1):7-15;
• Cancello R, Soranna D, Zambra G, Zambon A, Invitti C Determinants of the Lifestyle Changes during COVID-19 Pandemic in the Residents of Northern Italy. Int J Environ Res Public Health. 2020 Aug 28;17(17):6287.

European Society of Hypertension per la stesura e revisione delle guidelines for the management of high blood pressure in children and adolescents 2009 e 2016.

University of Warwick, Coventry  Diabetology, Clinical Immunology, Nutritional Biochemistry per studi sull’obesità infantile.

International Study group INTERPRET-DD per lo studio della depression nel diabete di tipo

Socio della Società Italiana di Diabetologia e della Società Italiana dell’Obesità.